3D-Blast is a novel shape-density based protein structure search and alignment tool which uses the
spherical polar Fourier (SPF) correlation technique.
This allows the shapes of protein domains to be superposed and compared in a completely
The current version of 3D-Blast uses a database of 12,881
CATH domain structures (CATH v3.4).
The 3D-Blast server may be used to superpose the 3D structures of a given pair
of proteins or to search a given protein structure against the entire CATH
database to give a ranked list of similar CATH families.
This could reveal unexpected similarities between different CATH families for example.
We aim to develop 3D-Blast further in order to build a novel and efficient shape-based index
for the CATH database.